Comparative Genomics and Genome Evolution
نویسندگان
چکیده
It has become a fundamental need to have genome sequence data due to the fact that the basic process of evolution is the change in DNA sequence and genome size. Recent advances in DNA sequencing technology have facilitated the availability of quite a large number of complete genome sequences from simplest prokaryotes to higher eukaryotes. The availability of whole genome sequence data at our fingertips can provide critical insight into how various genomic compositions have contributed to a contemporary understanding of molecular evolution. For this reason, comparative evolutionary genomics has become one of the most rapidly advancing disciplines in the biological sciences. The new generation of comparative genomics offers a powerful aid to studying evolutionary changes among organisms and identifying the genes that are conserved among species, and also the genes that give each organism its own specific characteristics. Informatics related to structural and functional genomics is potentially important in understanding the emergence of new phenotypic characters necessary for the adaptation of organisms. In addition, the evolutionary perspective of genes and genomes is also helpful in understanding disease susceptibility.
منابع مشابه
Comparative genomics - A perspective
The rapidly emerging field of comparative genomics has yielded dramatic results. Comparative genome analysis has become feasible with the availability of a number of completely sequenced genomes. Comparison of complete genomes between organisms allow for global views on genome evolution and the availability of many completely sequenced genomes increases the predictive power in deciphering the h...
متن کاملPrimate comparative genomics: lemur biology and evolution.
Comparative genome sequencing projects are providing insight into aspects of genome biology that raise new questions and challenge existing paradigms. Placement in the phylogenetic tree can often be a major determinant of which organism to choose for study. Lemurs hold a key position at the base of the primate evolutionary tree and will be highly informative for the genomics community by offeri...
متن کاملComparative genomics of human stem cell factor (SCF)
Stem cell factor (SCF) is a critical protein with key roles in the cell such as hematopoiesis, gametogenesis and melanogenesis. In the present study a comparative analysis on nucleotide sequences of SCF was performed in Humanoids using bioinformatics tools including NCBI-BLAST, MEGA6, and JBrowse. Our analysis of nucleotide sequences to find closely evolved organisms with high similarity by NCB...
متن کاملYeast evolution and comparative genomics.
Recent sequencing efforts and experiments have advanced our understanding of genome evolution in yeasts, particularly the Saccharomyces yeasts. The ancestral genome of the Saccharomyces sensu stricto complex has been subject to both whole-genome duplication, followed by massive sequence loss and divergence, and segmental duplication. In addition the subtelomeric regions are subject to further d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2012